Crossroads Between Innate and Adaptive Immunity IV by Diego Mourao-Sa, Soumit Roy (auth.), Peter D. Katsikis,

By Diego Mourao-Sa, Soumit Roy (auth.), Peter D. Katsikis, Stephen P. Schoenberger, Bali Pulendran (eds.)

This quantity offers a set of reports derived from paintings offered on the Aegean convention: “4th Crossroads among innate and adaptive immunity”. This assembly was once the fourth in a sequence, and assembled a group of scientists engaged on mechanisms in which the innate immune process of the host senses pathogens, the mobile and signaling networks that orchestrate the innate reaction and antigen presentation and adaptive immunity. the significance of the crosstalk among innate immunity and the adaptive immune reaction has just recently began to be liked. even though it is easily well-known that dendritic cells, NK cells, NK-T cells and T cells are all serious for the host reaction to pathogens, the respective fields that research the biology of those immune cells are inclined to exist in parallel worlds with minimal alternate of knowledge and concepts. This fragmentation hinders the mixing of those fields in the direction of a unified idea of host reaction. The Aegean convention “Crossroads among Innate and Adaptive Immunity” introduced jointly top overseas scientists and specialists to deal with severe components of Innate and Adaptive immunity anything useful for the improvement of extra effective medical alternate and crosspollination among those fields. This convention attracted scientists from around the world to debate their most modern findings at the numerous points of Innate and Adaptive immunity. The convention had constrained participation and a systematic and social application that maximized medical interchange via lecture displays, poster periods and casual discussions. ​

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Interestingly, processing of LLiP fragments by cDCs leading to cross-presentation is mediated by classical pathway of class I processing, including TAPs and proteasome, and it did not involve the lysosomal pathway of the cDCs. This means that LLiP fragments have to be exported into cytosol after phagocytosis to be processed by classical MHC class I pathway. Other mechanisms might intervene in favoring cross-presentation of cell-associated antigens, such as macroautophagy leading to the accumulation of autophagosomes [27].

3 Ror g t-Dependent ILCs: IL-17 and IL-22 Producers for Intestinal Homeostasis IL-17 is a pro-inflammatory cytokine that recruits neutrophils and promotes cytokine and antimicrobial peptide production from a variety of cells such as bronchial epithelial cells [96]. IL-17 has also been shown to have a role in the formation of germinal centers and neutrophilia in allergic asthma [97, 98]. IL-22 is a member of the IL-10 family and binds to its receptor, which is found exclusively on epithelial cells to induce the production of cytokines, microbial peptides, and mucins [99].

Eyerich S, Eyerich K, Pennino D et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 2009;119:3573–3585. 9. Cella M, Fuchs A, Vermi W et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009;457:722–725. 10. Luci C, Reynders A, Ivanov II et al. Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol. 2009;10:75–82.

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