By Jessica Amber Jennings, Joel David Bumgardner
Chitosan established Biomaterials: Tissue Engineering and Therapeutics, quantity 2, provides the newest info on chitosan, a ordinary polymer derived from the marine fabric chitin. Chitosan screens particular homes, such a lot significantly biocompatibility and biodegradability. it might probably even be simply tuned to switch its constitution or houses, making chitosan an exceptional candidate as a biomaterial. accordingly, chitosan is being built for plenty of biomedical features, starting from tissue engineering and implant coatings to drug and gene supply. This booklet presents readers with an entire assurance of the functions of chitosan-based biomaterials.
- Presents particular specialise in tissue engineering and therapeutics
- Provides entire remedy of all biomaterial purposes of chitosan
- Contains contributions via top researchers with huge adventure within the material
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Extra info for Chitosan Based Biomaterials Volume 2: Tissue Engineering and Therapeutics
2 Cancer imaging Cancer may be difficult to detect, but for some types of cancer, the earlier it is detected, the better are the chances of treating it effectively. Imaging techniques used to produce pictures of bodily tissues have become important for the early detection of cancers. Imaging is also important for determining the stage and the precise locations of cancer to aid in directing surgery and pharmocological treatments, as well as to determine whether cancer has returned. , 2011) and used in targeted cancer imaging.
1998). , 2013). , 2006). These are important to develop chitosan/pDNA complexes for therapeutic gene transfer applications. In efforts to translate laboratory level research into commercial use, chemical and biological modification of chitosan is necessary for effective delivery of nucleic acids to target cells. Mao et al. (2001) investigated the differences in biodistribution between PEGylated chitosan/DNA NPs and highly purified chitosan/DNA NPs in murine models. They observed that intravenous injection of PEGylated nanostructures were cleared slower than the unmodified formulations by the cellular reticuloendothelial system.
Advanced Drug Delivery Reviews 64, 223–236. , 2012. Nanoparticle-based combination therapy toward overcoming drug resistance in cancer. Biochemical Pharmacology 83, 1104–1111. , 2013. Advances in chitosan-based drug delivery vehicles. Nanoscale 5, 3103–3111. , 2001. An introduction to biodegradable materials for tissue engineering applications. Annals of the Academy of Medicine, Singapore 30, 183–191. , 2004. Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems.