Biochemical Protozoology As A Basis For Drug Design by ichael J.North, Graham H. Coombs

By ichael J.North, Graham H. Coombs

A compilation of articles on protozoological biochemistry which experiences the topic sector and provides info on present learn. integrated within the subject matters coated Are strength Metabolism Of Anaerobic Parasitic Protists, proteinases of African

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However, recently, sialic acid independent invasion has been shown for a variety of strains of P. falciparum and, under the appropriate circumstances, merozoites of P. , 1987) with glycophorins different from those of human red cells. P. knowlesi, which ordinarily does not invade Duffy-negative red cells, will do so after chymotrypsin treatment. Thus, there appear to be primary as well as secondary receptors involved in merozoite invasion. Putative merozoite surface proteins involved in binding to the red cell receptor are reported to be: for P.

In the de novo formation of pyrimidines (see below), a key step is the conversion of dihydroorotate to orotate. This step, catalysed by the enzyme dihydroorotate dehydrogenase, is mitochondrial in mammalian cells and is closely linked to the cytochrome chain to which electrons are passed directly via the ubiquinones, and for which oxygen is the final acceptor. Gutteridge et al. (1979) proposed that the oxygen utilized by Plasmodium sp. may be coupled to pyrimidine biosynthesis. In support of this is the finding of dihydroorotate dehydrogenase in extracts of plasmodia, and inhibition of such activity by CN and antimycin.

Despite this, mitochondrial DNA (mtDNA) has been obtained from P. lophurae, P. knowlesi and P. , 1989). Vaidya et al. (1989) reported the complete DNA sequence of a 5984-base-pair repeating unit in P. yoelii that had significant sequence homology with mitochondrial-encoded proteins such as cytochrome c oxidase subunit I, and cytochrome b. Two regions showed extensive similarity to the conserved central loop of the peptidyl transferase domain of the large rRNA of mitochondria and chloroplasts, suggesting that mtDNA in Plasmodium has less homology with the cytoplasmic rRNA of other eukaryotes.

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